2025 ICD-10-CM Diagnosis Code C81.0

by

Nodular lymphocyte predominant Hodgkin lymphoma

  • C81.0 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM C81.0 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of C81.0 – other international versions of ICD-10 C81.0 may differ.

The following code(s) above C81.0 contain annotation back-references

 that may be applicable to C81.0:

  • C00-D49  Neoplasms
  • C81-C96  Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C81  Hodgkin lymphoma

Clinical Information

  • A monoclonal b-cell neoplasm characterized by a nodular, or a nodular and diffuse, polymorphous proliferation of scattered large neoplastic cells known as popcorn or l&h cells; the l&h cells are cd15 negative, and rarely positive for cd30 antigen. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage i or ii); the prognosis of patients with stage i and stage ii disease is very good. Advanced stages have an unfavorable prognosis.
  • A rare type of hodgkin lymphoma, which is a cancer of the immune system. It is marked by the presence of a type of cell called a popcorn cell, which is different from the typical reed-sternberg cell found in classical hodgkin lymphoma. This type of hodgkin lymphoma may change into diffuse large b-cell lymphoma.
  • A subtype of classical hodgkin lymphoma. Most patients present with peripheral lymphadenopathy and limited stage disease (stage i or ii). The survival and progression free survival are slightly better than in other subtypes of classical hodgkin lymphoma. (who, 2001)

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to C81.0:

  • Code First: N16
  • Type 1 Excludes: C81.4

Diagnosis Index entries containing back-references to C81.0:

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