2025 ICD-10-CM Diagnosis Code C81.21

Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck

  • C81.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Mixed cellular Hodgkin lymph, nodes of head, face, and neck
  • The 2025 edition of ICD-10-CM C81.21 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of C81.21 – other international versions of ICD-10 C81.21 may differ.

The following code(s) above C81.21 contain annotation back-references

 that may be applicable to C81.21:

  • C00-D49  Neoplasms
  • C81-C96  Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C81  Hodgkin lymphoma
  • C81.2  Mixed cellularity Hodgkin lymphoma

Approximate Synonyms

  • Hodgkin lymphoma mix cellularity, head lymph node
  • Hodgkin mixed cellularity lymphoma, neck ln
  • Hodgkin’s disease, mixed cellularity of lymph nodes of head
  • Hodgkin’s disease, mixed cellularity of lymph nodes of neck

ICD-10-CM C81.21 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 011 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with mcc
  • 012 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with cc
  • 013 Tracheostomy for face, mouth and neck diagnoses or laryngectomy without cc/mcc
  • 820 Lymphoma and leukemia with major o.r. Procedures with mcc
  • 821 Lymphoma and leukemia with major o.r. Procedures with cc
  • 822 Lymphoma and leukemia with major o.r. Procedures without cc/mcc
  • 823 Lymphoma and non-acute leukemia with other procedures with mcc
  • 824 Lymphoma and non-acute leukemia with other procedures with cc
  • 825 Lymphoma and non-acute leukemia with other procedures without cc/mcc
  • 840 Lymphoma and non-acute leukemia with mcc
  • 841 Lymphoma and non-acute leukemia with cc
  • 842 Lymphoma and non-acute leukemia without cc/mcc

Convert C81.21 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): Revised code
    • New description: Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck
    • 2016 description: Mixed cellularity classical Hodgkin lymphoma, lymph nodes of head, face, and neck
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change
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