2025 ICD-10-CM Diagnosis Code C81.4

Lymphocyte-rich Hodgkin lymphoma

  • C81.4 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM C81.4 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of C81.4 – other international versions of ICD-10 C81.4 may differ.

Applicable To

  • Lymphocyte-rich classical Hodgkin lymphoma

Type 1 Excludes

  • nodular lymphocyte predominant Hodgkin lymphoma (C81.0-)

The following code(s) above C81.4 contain annotation back-references

 that may be applicable to C81.4:

  • C00-D49  Neoplasms
  • C81-C96  Malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C81  Hodgkin lymphoma

Clinical Information

  • A subtype of classical hodgkin lymphoma. Most patients present with peripheral lymphadenopathy and limited stage disease (stage i or ii). The survival and progression free survival are slightly better than in other subtypes of classical hodgkin lymphoma. (who, 2001)

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): Revised code
    • New description: Lymphocyte-rich Hodgkin lymphoma
    • 2016 description: Lymphocyte-rich classical Hodgkin lymphoma
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to C81.4:

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