Diffuse large B-cell lymphoma
- C83.3 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2025 edition of ICD-10-CM C83.3 became effective on October 1, 2024.
- This is the American ICD-10-CM version of C83.3 – other international versions of ICD-10 C83.3 may differ.
Applicable To
- Anaplastic diffuse large B-cell lymphoma
- CD30-positive diffuse large B-cell lymphoma
- Centroblastic diffuse large B-cell lymphoma
- Diffuse large B-cell lymphoma, subtype not specified
- Immunoblastic diffuse large B-cell lymphoma
- Plasmablastic diffuse large B-cell lymphoma
- T-cell rich diffuse large B-cell lymphoma
Type 1 Excludes
- mediastinal (thymic) large B-cell lymphoma (C85.2-)
- mature T/NK-cell lymphomas (C84.-)
The following code(s) above C83.3 contain annotation back-references
that may be applicable to C83.3:
- C00-D49 Neoplasms
- C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue
- C83 Non-follicular lymphoma
Clinical Information
- A non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include t-cell/histiocyte rich large b-cell lymphoma, primary diffuse large b-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large b-cell lymphoma, leg type, and alk-positive large b-cell lymphoma.
- A non-hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic b lymphocytes. It is the most frequently seen type of non-hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, t-cell/histiocyte rich lymphoma, anaplastic lymphoma, plasmablastic lymphoma, and diffuse large b-cell lymphoma with expression of full-length alk. (who, 2001)
- A type of b-cell non-hodgkin lymphoma (cancer of the immune system) that is usually aggressive (fast-growing). It is the most common type of non-hodgkin lymphoma, and is marked by rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow, or other organs. Other symptoms include fever, night sweats, and weight loss. There are several subtypes of diffuse large b-cell lymphoma.
- Malignant lymphoma composed of large b lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of b-lymphocytes at midstage in the process of differentiation.
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- 2024 (effective 10/1/2023): No change
- 2025 (effective 10/1/2024): No change
Code annotations containing back-references to C83.3:
- Type 1 Excludes: C83.8, C88.4
Diagnosis Index entries containing back-references to C83.3:
- Lymphoma (of) (malignant) C85.90
- diffuse large cell C83.3-
- anaplastic C83.3-
- B-cell C83.3-
- CD30-positive C83.3-
- centroblastic C83.3-
- immunoblastic C83.3-
- plasmablastic C83.3-
- subtype not specified C83.3-
- T-cell rich C83.3-
- diffuse large cell C83.3-