2025 ICD-10-CM Diagnosis Code C91

Lymphoid leukemia

  • C91 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM C91 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of C91 – other international versions of ICD-10 C91 may differ.

Type 1 Excludes

  • personal history of leukemia (Z85.6)

The following code(s) above C91 contain annotation back-references

 that may be applicable to C91:

  • C00-D49  Neoplasms
  • C81-C96  Malignant neoplasms of lymphoid, hematopoietic and related tissue

Clinical Information

  • A malignant lymphocytic neoplasm of b-cell or t-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias.
  • A progressive, proliferative disease of blood cells, originating from lymphoid cells.
  • A type of cancer in which the bone marrow makes too many lymphocytes (white blood cells).
  • Leukemia associated with hyperplasia and overactivity of the lymphoid tissue; there are increased numbers of circulating malignant lymphocytes and lymphoblasts.
  • Leukemia associated with hyperplasia of the lymphoid tissues and increased numbers of circulating malignant lymphocytes and lymphoblasts.

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to C91:

  • Type 1 Excludes: D72.825
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