Malignant mast cell neoplasm
- C96.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2025 edition of ICD-10-CM C96.2 became effective on October 1, 2024.
- This is the American ICD-10-CM version of C96.2 – other international versions of ICD-10 C96.2 may differ.
Type 1 Excludes
- indolent mastocytosis (D47.02)
- mast cell leukemia (C94.30)
- mastocytosis (congenital) (cutaneous) (Q82.2)
The following code(s) above C96.2 contain annotation back-references
that may be applicable to C96.2:
- C00-D49 Neoplasms
- C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue
- C96 Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue
Approximate Synonyms
- Lymphoma intra abdominal, mast cell
- Lymphoma intrapelvic, mast cell
- Lymphoma intrathoracic, mast cell
- Lymphoma multiple sites, mast cell
- Lymphoma spleen, mast cell
- Lymphoma, mast cell
- Malignant mast cell tumor (clinical)
- Malignant mast cell tumor of intra-abdominal lymph nodes
- Malignant mast cell tumor of intrapelvic lymph nodes
- Malignant mast cell tumor of intrathoracic lymph nodes
- Malignant mast cell tumor of lymph nodes of axilla
- Malignant mast cell tumor of lymph nodes of head
- Malignant mast cell tumor of lymph nodes of inguinal region
- Malignant mast cell tumor of lymph nodes of lower limb
- Malignant mast cell tumor of lymph nodes of multiple sites
- Malignant mast cell tumor of lymph nodes of neck
- Malignant mast cell tumor of lymph nodes of upper limb
- Malignant mast cell tumor, arm ln
- Malignant mast cell tumor, axillary ln
- Malignant mast cell tumor, head ln
- Malignant mast cell tumor, inguinal ln
- Malignant mast cell tumor, leg ln
- Malignant mast cell tumor, neck ln
- Mast cell malignancy of spleen
- Mastocytosis, systemic
- Systemic mast cell disease
Clinical Information
- A form of systemic mastocytosis in which patients have impaired organ functions due to multifocal infiltrates of pathological mast cells in bone marrow, liver, spleen, gastrointestinal tract, or skeletal system. The cytomorphology shows a low to high grade.
- A rare entity characterized by localized but destructive growth of a tumor consisting of highly atypical, immature mast cells.(who, 2001)
- A unifocal malignant tumor that consists of atypical pathological mast cells without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.
- An aggressive and progressive mast cell neoplasm characterized by systemic infiltration of internal organs by aggregates of neoplastic mast cells.
- An aggressive and progressive mast cell neoplasm characterized by systemic infiltration of internal organs by aggregates of neoplastic mast cells. There is no evidence of mast cell leukemia or clonal hematologic malignancy. Clinical symptoms include hepatomegaly, splenomegaly, portal hypertension, malabsorption syndrome, and pathologic fractures.
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): Deleted code
- 2018 (effective 10/1/2017): New code
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- 2024 (effective 10/1/2023): No change
- 2025 (effective 10/1/2024): No change
Code annotations containing back-references to C96.2:
- Type 1 Excludes: D47.0, D89.4, Q82.2