2025 ICD-10-CM Diagnosis Code E04.1

Nontoxic single thyroid nodule

• E04.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2025 edition of ICD-10-CM E04.1 became effective on October 1, 2024.
• This is the American ICD-10-CM version of E04.1 – other international versions of ICD-10 E04.1 may differ.

Applicable To

• Colloid nodule (cystic) (thyroid)
• Nontoxic uninodular goiter
• Thyroid (cystic) nodule NOS

The following code(s) above E04.1 contain annotation back-references

 that may be applicable to E04.1:

• E00-E89  Endocrine, nutritional and metabolic diseases
• E04  Other nontoxic goiter

Approximate Synonyms

• Cyst of thyroid
• Dominant nodule of thyroid
• Dominant thyroid nodule
• Functioning thyroid nodule
• Non-toxic uninodular goiter
• Thyroid cyst
• Thyroid goiter, nontoxic, uninodular
• Thyroid nodule
• Thyroid nodule, functioning

ICD-10-CM E04.1 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

• 011 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with mcc
• 012 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with cc
• 013 Tracheostomy for face, mouth and neck diagnoses or laryngectomy without cc/mcc
• 643 Endocrine disorders with mcc
• 644 Endocrine disorders with cc
• 645 Endocrine disorders without cc/mcc

Convert E04.1 to ICD-9-CMCode History

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change
• 2024 (effective 10/1/2023): No change
• 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to E04.1:

• Colloid nodule E04.1 (of thyroid) (cystic)
• Cyst (colloid) (mucous) (simple) (retention)
  • thyroid E04.1 (gland)
• Goiter (plunging) (substernal) E04.9
  • uninodular (nontoxic) E04.1
  • nontoxicE04.9
    • uninodular E04.1
• Nodule(s)
  • thyroid (cold) (gland) (nontoxic) E04.1
  • colloid E04.1 (cystic)
• Struma – see also Goiter
  • nodosa (simplex) E04.9
    • uninodular E04.1
• Thyroid (gland) (body) – see also condition
  • nodule E04.1 (cystic) (nontoxic) (single)