2025 ICD-10-CM Diagnosis Code E05.0

Thyrotoxicosis with diffuse goiter

  • E05.0 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM E05.0 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E05.0 – other international versions of ICD-10 E05.0 may differ.

Applicable To

  • Exophthalmic or toxic goiter NOS
  • Graves’ disease
  • Toxic diffuse goiter

The following code(s) above E05.0 contain annotation back-references

 that may be applicable to E05.0:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E05  Thyrotoxicosis [hyperthyroidism]

Clinical Information

  • A common form of hyperthyroidism with a diffuse hyperplastic goiter. It is an autoimmune disorder that produces antibodies against the thyroid stimulating hormone receptor. These autoantibodies activate the tsh receptor, thereby stimulating the thyroid gland and hypersecretion of thyroid hormones. These autoantibodies can also affect the eyes (graves ophthalmopathy) and the skin (graves dermopathy).
  • A condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
  • Exophthalmos occurring in association with goiter; hyperthyroidism with protrusion of the eyeballs.
  • Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithelial cells. As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones.

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to E05.0:

  • Code First: I43
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