2025 ICD-10-CM Diagnosis Code E10.21

Type 1 diabetes mellitus with diabetic nephropathy

• E10.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2025 edition of ICD-10-CM E10.21 became effective on October 1, 2024.
• This is the American ICD-10-CM version of E10.21 – other international versions of ICD-10 E10.21 may differ.

Applicable To

• Type 1 diabetes mellitus with intercapillary glomerulosclerosis
• Type 1 diabetes mellitus with intracapillary glomerulonephrosis
• Type 1 diabetes mellitus with Kimmelstiel-Wilson disease

The following code(s) above E10.21 contain annotation back-references

 that may be applicable to E10.21:

• E00-E89  Endocrine, nutritional and metabolic diseases
• E10  Type 1 diabetes mellitus

Approximate Synonyms

• Diabetes type 1 with diabetic nephropathy
• Renal disorder associated with type i diabetes mellitus

ICD-10-CM E10.21 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

• 008 Simultaneous pancreas and kidney transplant
• 010 Pancreas transplant
• 019 Simultaneous pancreas and kidney transplant with hemodialysis
• 673 Other kidney and urinary tract procedures with mcc
• 674 Other kidney and urinary tract procedures with cc
• 675 Other kidney and urinary tract procedures without cc/mcc
• 698 Other kidney and urinary tract diagnoses with mcc
• 699 Other kidney and urinary tract diagnoses with cc
• 700 Other kidney and urinary tract diagnoses without cc/mcc

Convert E10.21 to ICD-9-CMCode History

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change
• 2024 (effective 10/1/2023): No change
• 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to E10.21:

• Diabetes, diabetic (mellitus) (sugar) E11.9
  • type 1E10.9
    • with
      • glomerulonephrosis, intracapillary E10.21
      • glomerulosclerosis, intercapillary E10.21
      • Kimmelstiel-Wilson disease E10.21
      • nephropathy E10.21