2025 ICD-10-CM Diagnosis Code E11.21

Type 2 diabetes mellitus with diabetic nephropathy

  • E11.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM E11.21 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E11.21 – other international versions of ICD-10 E11.21 may differ.

Applicable To

  • Type 2 diabetes mellitus with intercapillary glomerulosclerosis
  • Type 2 diabetes mellitus with intracapillary glomerulonephrosis
  • Type 2 diabetes mellitus with Kimmelstiel-Wilson disease

The following code(s) above E11.21 contain annotation back-references

 that may be applicable to E11.21:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E11  Type 2 diabetes mellitus

Approximate Synonyms

  • Diabetes type 2 with nephrotic syndrome
  • Diabetes, type 2 with nephropathy
  • Nephrotic syndrome due to type 2 diabetes mellitus
  • Persistent proteinuria associated with type ii diabetes mellitus
  • Renal disorder associated with type ii diabetes mellitus

ICD-10-CM E11.21 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 008 Simultaneous pancreas and kidney transplant
  • 010 Pancreas transplant
  • 019 Simultaneous pancreas and kidney transplant with hemodialysis
  • 698 Other kidney and urinary tract diagnoses with mcc
  • 699 Other kidney and urinary tract diagnoses with cc
  • 700 Other kidney and urinary tract diagnoses without cc/mcc

Convert E11.21 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to E11.21:

  • Diabetes, diabetic (mellitus) (sugar) E11.9
    • with
      • glomerulonephrosis, intracapillary E11.21
      • glomerulosclerosis, intercapillary E11.21
      • Kimmelstiel-Wilson disease E11.21
      • nephropathy E11.21
    • type 2E11.9
      • with
        • glomerulonephrosis, intracapillary E11.21
        • glomerulosclerosis, intercapillary E11.21
        • Kimmelstiel-Wilson disease E11.21
        • nephropathy E11.21
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