2025 ICD-10-CM Diagnosis Code E21

by

Hyperparathyroidism and other disorders of parathyroid gland

  • E21 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM E21 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E21 – other international versions of ICD-10 E21 may differ.

Type 1 Excludes

  • adult osteomalacia (M83.-)
  • ectopic hyperparathyroidism (E34.2)
  • hungry bone syndrome (E83.81)
  • infantile and juvenile osteomalacia (E55.0)

Type 2 Excludes

  • familial hypocalciuric hypercalcemia (E83.52)

The following code(s) above E21 contain annotation back-references

 that may be applicable to E21:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E20-E35  Disorders of other endocrine glands

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to E21:

  • Code First: M14.8
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