2025 ICD-10-CM Diagnosis Code E23.0

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Hypopituitarism

  • E23.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM E23.0 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E23.0 – other international versions of ICD-10 E23.0 may differ.

Applicable To

  • Fertile eunuch syndrome
  • Hypogonadotropic hypogonadism
  • Idiopathic growth hormone deficiency
  • Isolated deficiency of gonadotropin
  • Isolated deficiency of growth hormone
  • Isolated deficiency of pituitary hormone
  • Kallmann’s syndrome
  • Lorain-Levi short stature
  • Necrosis of pituitary gland (postpartum)
  • Panhypopituitarism
  • Pituitary cachexia
  • Pituitary insufficiency NOS
  • Pituitary short stature
  • Sheehan’s syndrome
  • Simmonds’ disease

The following code(s) above E23.0 contain annotation back-references

 that may be applicable to E23.0:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E20-E35  Disorders of other endocrine glands
  • E23  Hypofunction and other disorders of the pituitary gland

Approximate Synonyms

  • Anterior pituitary hormone deficiency
  • Female infertility due to pituitary disorder
  • Female infertility of pituitary origin
  • Follicle stimulating hormone deficiency
  • Fsh – follicle stimulating hormone deficiency
  • Gonadotropin deficiency, isolated
  • Growth hormone deficiency
  • Growth hormone deficiency after bone marrow transplant
  • Growth hormone deficiency, bone marrow transplant
  • Growth hormone deficiency, isolated
  • Hypogonadism with anosmia
  • Hypogonadism, anosmia
  • Hypogonadotropic hypogonadism
  • Isolated gonadotropin deficiency
  • Isolated somatotropin deficiency
  • Lh – luteinizing hormone deficiency
  • Luteinizing hormone deficiency
  • Panhypopituitarism
  • Partial growth hormone deficiency
  • Partial hypopituitarism
  • Pituitary dwarfism
  • Somatotropin deficiency, partial

Clinical Information

  • A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • A form of dwarfism caused by complete or partial growth hormone deficiency, resulting from either the lack of growth hormone-releasing factor from the hypothalamus or from the mutations in the growth hormone gene (gh1) in the pituitary gland. It is also known as type i pituitary dwarfism. Human hypophysial dwarf is caused by a deficiency of human growth hormone during development.
  • A genetically heterogeneous disorder caused by hypothalamic gnrh deficiency and olfactory nerve defects. It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects. It can be transmitted as an x-linked (genetic diseases, x-linked), an autosomal dominant, or an autosomal recessive trait.
  • A syndrome, sometimes considered as three separate entities (kalmann syndromes 1, 2, and 3), characterized mainly by reduced hypothalamic function and reduced pituitary gonadotropic activity and deficiency of gonadotropin-releasing hormone with resulting hypogonadism and absent or reduced sense of smell due to agenesis of the olfactory bulbs. Associated anomalies include cleft palate, neurosensory hearing loss, congenital heart defect, intestinal malrotation, renal agenesis, hypertension, mental retardation, color blindness, and other defects. Most abnormalities occur in types 1 and 2; type 3 is marked mainly by hypogonadotropic hypogonadism, anosmia, and craniofacial abnormalities.
  • An x-linked or autosomal dominant genetic syndrome characterized by hypogonadotropic hypogonadism and anosmia.
  • Anosmia due to failure of the olfactory lobes to develop, with secondary hypogonadism due to gonadotropic hormone deficiency.
  • Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including lh; follicle stimulating hormone; somatotropin; and corticotropin). This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including luteinizing hormone, follicle stimulating hormone, somatotropin; and corticotropin); may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • Form of dwarfism due to deficient release of growth hormone which may result from dysfunction of the hypothalamus or anterior pituitary gland.

ICD-10-CM E23.0 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E23.0 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to E23.0:

  • Type 1 Excludes: E28, E29, E34.3, R62
  • Type 2 Excludes: N97

Diagnosis Index entries containing back-references to E23.0:

  • Ahumada-del Castillo syndrome E23.0
  • Brissaud’s
    • infantilism or dwarfism E23.0
  • CachexiaR64
    • hypophyseal E23.0
    • hypopituitary E23.0
    • pituitary E23.0
    • Simmonds’ E23.0
  • Decrease (d)
    • function
      • pituitary (gland) (anterior) (lobe) E23.0
        • posterior E23.0 (lobe)
      • ovary in hypopituitarism E23.0
  • Deficiency, deficient
    • hormone
      • anterior pituitary (partial) E23.0
        • growth E23.0
      • growth E23.0 (isolated)
      • pituitary E23.0
    • gonadotropin E23.0 (isolated)
    • growth hormone E23.0 (idiopathic) (isolated)
    • pituitary hormone E23.0 (isolated)
  • DwarfismE34.328 – see also Short, stature
    • hypophyseal E23.0
    • Lorain E23.0 (-Levi)
    • pituitary E23.0
  • EunuchoidismE29.1
    • hypogonadotropic E23.0
  • Fertile eunuch syndrome E23.0
  • HypoadrenocorticismE27.40
    • pituitary E23.0
  • Hypofunction
    • pituitary E23.0 (gland) (anterior)
  • Hypogonadism
    • hypogonadotropic E23.0
    • pituitary E23.0
  • Hypophyseal, hypophysis – see also condition
    • dwarfism E23.0
  • Hypopituitarism (juvenile) E23.0
  • Hyposecretion
    • ACTH E23.0
  • Infancy, infantile, infantilism – see also condition
    • Lorain E23.0
    • pituitary E23.0
  • Infertility
    • femaleN97.9
      • associated with
        • pituitary-hypothalamic origin E23.0
  • Insufficiency, insufficient
    • pituitary E23.0
  • Kallmann’s syndrome E23.0
  • Lorain E23.0 (-Levi)
  • MyopathyG72.9
    • in (due to)
      • hypopituitarism E23.0
  • Necrosis, necrotic (ischemic) – see also Gangrene
    • pituitary (gland) E23.0
  • Panhypopituitarism E23.0
    • prepubertal E23.0
  • Sheehan’s disease or syndrome E23.0
  • Simmonds’ cachexia or disease E23.0
  • Syndrome – see also Disease
    • fertile eunuch E23.0
    • hypopituitarism E23.0
    • infantilism E23.0 (pituitary)
    • postpartum panhypopituitary E23.0 (Sheehan)
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