2025 ICD-10-CM Diagnosis Code E25.0

Congenital adrenogenital disorders associated with enzyme deficiency

E25.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Short description: Congenital adrenogenital disorders assoc w enzyme deficiency
The 2025 edition of ICD-10-CM E25.0 became effective on October 1, 2024.
This is the American ICD-10-CM version of E25.0 – other international versions of ICD-10 E25.0 may differ.

Applicable To

The following code(s) above E25.0 contain annotation back-references

that may be applicable to E25.0:

Approximate Synonyms

3 beta-hydroxysteroid dehydrogenase deficiency
Adrenal hyperplasia, congenital
Adrenal hyperplasia, congenital, simple virilizing
Adrenal hyperplasia, congenital, virilizing, non salt
Congenital adrenal hyperplasia
Congenital adrenal hyperplasia, undervirilized xy due to 17-alpha hydroxylase deficiency
Congenital adrenal hyperplasia, virilizing, non-salt-losing
Congenital adrenal hyperplasia, virilizing, salt-losing
Late onset congenital adrenal hyperplasia
Steroid 21-monooxygenase deficiency, simple virilizing type
Undervirilized xy, 3-beta hydroxysteroid deficiency
Undervirilized xy, congenital adrenal hyperplasis,

Clinical Information

A genetic disorder characterized by defects in the synthesis of cortisol and/or aldosterone, resulting in hyperplasia of the adrenal cortical cells.
A group of inherited disorders of the adrenal glands, caused by enzyme defects in the synthesis of cortisol (hydrocortisone) and/or aldosterone leading to accumulation of precursors for androgens. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in steroid 21-hydroxylase; steroid 11-beta-hydroxylase; steroid 17-alpha-hydroxylase; 3-beta-hydroxysteroid dehydrogenase (3-hydroxysteroid dehydrogenases); testosterone 5-alpha-reductase; or steroidogenic acute regulatory protein; among others, underlie these disorders.
Group of syndromes caused by inherited defects in cortisol and/or aldosterone biosynthesis; acth elevation is caused by low levels of cortisol, whose production is impaired by absence or deficiency of one of the five enzymes necessary for its synthesis from cholesterol.

ICD-10-CM E25.0 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

Convert E25.0 to ICD-9-CMCode History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change
2024 (effective 10/1/2023): No change
2025 (effective 10/1/2024): No change

Code annotations containing back-references to E25.0:

Diagnosis Index entries containing back-references to E25.0:

Adrenogenital syndromeE25.9
- congenital E25.0
- salt loss E25.0
Adrenogenitalism, congenital E25.0
Defect, defectiveQ89.9
- 3-beta-hydroxysteroid dehydrogenase E25.0
- 11-hydroxylase E25.0
- 21-hydroxylase E25.0
Deficiency, deficient
- 3-beta hydroxysteroid dehydrogenase E25.0
- 11-hydroxylase E25.0
- 21-hydroxylase E25.0
HyperadrenocorticismE24.9
- congenital E25.0
Hyperfunction
- adrenal cortex, not associated with Cushing’s syndromeE27.0
  - virilismE25.9
    - congenital E25.0
Hyperplasia, hyperplastic
- adrenal (capsule) (cortex) (gland) E27.8
  - with
    - sexual precocity (male) E25.9
      - congenital E25.0
    - virilism, adrenalE25.9
      - congenital E25.0
    - virilization (female) E25.9
      - congenital E25.0
  - congenital E25.0
    - salt-losing E25.0
Macrogenitosomia (adrenal) (male) (praecox) E25.9
- congenital E25.0
Masculinization (female) E25.9
- congenital E25.0
Precocity, sexual (constitutional) (cryptogenic) (female) (idiopathic) (male) E30.1
- with adrenal hyperplasiaE25.9
  - congenital E25.0
PseudohermaphroditismQ56.3
- femaleQ56.2 – see also Disorder, adrenogenital
  - adrenal E25.0 (congenital)
Syndrome – see also Disease
- adrenogenitalE25.9
  - congenital, associated with enzyme deficiency E25.0
Virilism (adrenal) E25.9
- congenital E25.0
Virilization (female) (suprarenal) E25.9
- congenital E25.0