2025 ICD-10-CM Diagnosis Code E31.0

Autoimmune polyglandular failure

• E31.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2025 edition of ICD-10-CM E31.0 became effective on October 1, 2024.
• This is the American ICD-10-CM version of E31.0 – other international versions of ICD-10 E31.0 may differ.

Applicable To

• Schmidt’s syndrome

The following code(s) above E31.0 contain annotation back-references

 that may be applicable to E31.0:

• E00-E89  Endocrine, nutritional and metabolic diseases
• E20-E35  Disorders of other endocrine glands
• E31  Polyglandular dysfunction

Approximate Synonyms

• Autoimmune polyendocrinopathy
• Lloyd syndrome
• Polyglandular autoimmune syndrome, type 2
• Schmidts syndrome

Clinical Information

• A rare genetic syndrome characterized by autoantibodies production against more than one endocrine organ. The range of endocrinopathies includes hypoparathyroidism, adrenal insufficiency, hypogonadism, type 1 diabetes mellitus and hypothyroidism.
• An autoimmune diseases affecting multiple endocrine organs
• Autoimmune diseases affecting multiple endocrine organs. Type i is characterized by childhood onset and chronic mucocutaneous candidiasis (candidiasis, chronic mucocutaneous), while type ii exhibits any combination of adrenal insufficiency (addison’s disease), lymphocytic thyroiditis (thyroiditis, autoimmune;), hypoparathyroidism; and gonadal failure. In both types organ-specific antibodies against a variety of endocrine glands have been detected. The type ii syndrome differs from type i in that it is associated with hla-a1 and b8 haplotypes, onset is usually in adulthood, and candidiasis is not present.

ICD-10-CM E31.0 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

• 643 Endocrine disorders with mcc
• 644 Endocrine disorders with cc
• 645 Endocrine disorders without cc/mcc

Convert E31.0 to ICD-9-CMCode History

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change
• 2024 (effective 10/1/2023): No change
• 2025 (effective 10/1/2024): No change

Code annotations containing back-references to E31.0:

• Code First: E20.812, E20.812

Diagnosis Index entries containing back-references to E31.0:

• Atrophy, atrophic (of)
  • pluriglandularE31.8
    • autoimmune E31.0
• Deficiency, deficient
  • polyglandularE31.8
    • autoimmune E31.0
• Failure, failed
  • polyglandular, autoimmune E31.0
• Insufficiency, insufficient
  • progressive pluriglandular E31.0
• Polyglandular
  • deficiency E31.0
• Schmidt’s syndrome E31.0 (polyglandular, autoimmune)
• Syndrome – see also Disease
  • pluriglandular (compensatory) E31.8
    • autoimmune E31.0
  • polyglandularE31.8
    • autoimmune E31.0
  • autoimmune polyglandular E31.0
  • thyroid-adrenocortical insufficiency E31.0