Pure hypercholesterolemia
- E78.0 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2025 edition of ICD-10-CM E78.0 became effective on October 1, 2024.
- This is the American ICD-10-CM version of E78.0 – other international versions of ICD-10 E78.0 may differ.
The following code(s) above E78.0 contain annotation back-references
that may be applicable to E78.0:
- E00-E89 Endocrine, nutritional and metabolic diseases
- E70-E88 Metabolic disorders
- E78 Disorders of lipoprotein metabolism and other lipidemias
Approximate Synonyms
- Familial hypercholesterolemia
- Familial hypercholesterolemia – homozygous
- High cholesterol
- Hyperbetalipoproteinemia
- Hypercholesterolemia
- Hypercholesterolemia, familial
- Hypercholesterolemia, familial, homozygous
Clinical Information
- A group of familial disorders characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins (pre-beta lipoproteins).
- Characterized by increased plasma concentration of cholesterol carried in low density lipoproteins (ldl) and by a deficiency in a cell surface receptor which regulates ldl degradation and cholesterol synthesis.
- Hypercholesterolemia that is caused by mutation in the low density lipoprotein receptor gene. This receptor defect prevents ldl binding to the cell membrane and uptake of cholesterol which normally suppresses further cholesterol synthesis.
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): Deleted code
- 2017 (effective 10/1/2016): New code
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- 2024 (effective 10/1/2023): No change
- 2025 (effective 10/1/2024): No change