2025 ICD-10-CM Diagnosis Code E85

by

Amyloidosis

  • E85 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM E85 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E85 – other international versions of ICD-10 E85 may differ.

Type 2 Excludes

  • Alzheimer’s disease (G30.0-)

The following code(s) above E85 contain annotation back-references

 that may be applicable to E85:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E70-E88  Metabolic disorders

Clinical Information

  • A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
  • A group of diseases in which protein builds up in certain organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause), secondary (caused by another disease, including some types of cancer, such as multiple myeloma), or hereditary (passed down from parents to children). Many organs are affected by amyloidosis. The organs affected may depend on whether the amyloidosis is the primary, secondary, or hereditary form.
  • A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (plasma cell neoplasm) or secondary (caused by a long standing infection or another disease or some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often affects the spleen, kidneys, liver, and adrenal glands.
  • A group of diseases in which protein is deposited in specific organs or throughout the body.
  • A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of amyloid. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
  • Amyloidosis occurs when abnormal proteins build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should. There are three main types of amyloidosis:
    • primary – with no known cause
    • secondary – caused by another disease, including some types of cancer
    • familial – passed down through genes
    treatment depends on the type of amyloidosis you have.
  • Any disease manifested by the pathogenic accumulation of amyloid in organs and tissues.

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to E85:

  • Code First: N08, N29, I79.8, J99, D77, K77, L99, M14.8, G32.8, G63, G99.0, G99.8, H42, I43, I68.0
  • Type 1 Excludes: E27.1
  • Type 2 Excludes: N07, N07, K76

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