2025 ICD-10-CM Diagnosis Code E88.82

Obesity due to disruption of MC4R pathway

• E88.82 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• ICD-10-CM E88.82 is a new 2025 ICD-10-CM code that became effective on October 1, 2024.
• This is the American ICD-10-CM version of E88.82 – other international versions of ICD-10 E88.82 may differ.

Use Additional

• code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)

The following code(s) above E88.82 contain annotation back-references

 that may be applicable to E88.82:

• E00-E89  Endocrine, nutritional and metabolic diseases
• E70-E88  Metabolic disorders
• E88  Other and unspecified metabolic disorders

ICD-10-CM E88.82 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

• 642 Inborn and other disorders of metabolism

Code History

• 2025 (effective 10/1/2024): New code

Diagnosis Index entries containing back-references to E88.82:

• ObesityE66.9
  • due to
    • gene mutation
      • leptin E88.82 (LEP)
      • leptin receptor E88.82 (LEPR)
      • melanocortin 4 Receptor E88.82 (MC4R)
      • nuclear receptor coactivator 1 E88.82 (NCOA1)
      • proopiomelanocortin E88.82 (POMC)
      • proprotein convertase subtilisin/kexin type 1 E88.82 (PCSK1)
      • src homology 2B adaptor signaling protein E88.82 (SH2B1)
    • disruption of MC4R pathway E88.82