2025 ICD-10-CM Diagnosis Code I21.21

ST elevation (STEMI) myocardial infarction involving left circumflex coronary artery

  • I21.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: STEMI involving left circumflex coronary artery
  • The 2025 edition of ICD-10-CM I21.21 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of I21.21 – other international versions of ICD-10 I21.21 may differ.

Applicable To

  • ST elevation (STEMI) myocardial infarction involving oblique marginal coronary artery

The following code(s) above I21.21 contain annotation back-references

 that may be applicable to I21.21:

  • I00-I99  Diseases of the circulatory system
  • I20-I25  Ischemic heart diseases
  • I21  Acute myocardial infarction
  • I21.2  ST elevation (STEMI) myocardial infarction of other sites

Approximate Synonyms

  • Acute heart attack, left circumflex coronary artery
  • Acute st segment elevation myocardial infarction due to occlusion of left circumflex coronary artery

ICD-10-CM I21.21 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 280 Acute myocardial infarction, discharged alive with mcc
  • 281 Acute myocardial infarction, discharged alive with cc
  • 282 Acute myocardial infarction, discharged alive without cc/mcc
  • 283 Acute myocardial infarction, expired with mcc
  • 284 Acute myocardial infarction, expired with cc
  • 285 Acute myocardial infarction, expired without cc/mcc

Convert I21.21 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to I21.21:

Diagnosis Index entries containing back-references to I21.21:

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