2025 ICD-10-CM Diagnosis Code I25.1

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Atherosclerotic heart disease of native coronary artery

  • I25.1 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2025 edition of ICD-10-CM I25.1 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of I25.1 – other international versions of ICD-10 I25.1 may differ.

Applicable To

  • Atherosclerotic cardiovascular disease
  • Coronary (artery) atheroma
  • Coronary (artery) atherosclerosis
  • Coronary (artery) disease
  • Coronary (artery) sclerosis

Use Additional

  • code, if applicable, to identify:
  • coronary atherosclerosis due to calcified coronary lesion (I25.84)
  • coronary atherosclerosis due to lipid rich plaque (I25.83)

Type 2 Excludes

  • atheroembolism (I75.-)
  • atherosclerosis of coronary artery bypass graft(s) and transplanted heart (I25.7-)

The following code(s) above I25.1 contain annotation back-references

 that may be applicable to I25.1:

  • I00-I99  Diseases of the circulatory system
  • I20-I25  Ischemic heart diseases
  • I25  Chronic ischemic heart disease

Clinical Information

  • A disease in which there is a narrowing or blockage of the coronary arteries (blood vessels that carry blood and oxygen to the heart). Coronary artery disease is usually caused by atherosclerosis (a build up of fatty material and plaque inside the coronary arteries). The disease may cause chest pain, shortness of breath during exercise, and heart attacks. The risk of coronary artery disease is increased by having a family history of coronary artery disease before age 50, older age, smoking tobacco, high blood pressure, high cholesterol, diabetes, lack of exercise, and obesity.
  • A thickening and loss of elasticity of the walls of arteries that occurs with formation of atherosclerotic plaques within the arterial intima.
  • Age, lifestyle, diet, and gene related degeneration of arteries due to deposition of lipoid plaques (atheromas) on inner arterial walls; main cause of coronary artery disease, a leading cause of death.
  • An imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. It is a form of myocardial ischemia (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
  • Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body and can lead to serious problems, including
    • coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack.
    • carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke.
    • peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections.
    atherosclerosis usually doesn’t cause symptoms until it severely narrows or totally blocks an artery. Many people don’t know they have the disease until they have a medical emergency.a physical examination, imaging and other diagnostic tests can tell if you have it. Treatments include medicines, and medical procedures or surgery. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress.
  • Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.
  • Coronary artery disease (cad) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women.cad happens when the arteries that supply blood to heart muscle become hardened and narrowed. This is due to the buildup of cholesterol and other material, called plaque, on their inner walls. This buildup is called atherosclerosis. As it grows, less blood can flow through the arteries. As a result, the heart muscle can’t get the blood or oxygen it needs. This can lead to chest pain (angina) or a heart attack. Most heart attacks happen when a blood clot suddenly cuts off the hearts’ blood supply, causing permanent heart damage. Over time, cad can also weaken the heart muscle and contribute to heart failure and arrhythmias. Heart failure means the heart can’t pump blood well to the rest of the body. Arrhythmias are changes in the normal beating rhythm of the heart.
  • Deposition of cholesterol and lipid in the inner layer of the blood vessel
  • Imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow.
  • Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (cabg); previous percutaneous coronary intervention (pci); previous myocardial infarction.
  • Thickening and loss of elasticity of the coronary arteries, leading to progressive arterial insufficiency (coronary disease).

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to I25.1:

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