2025 ICD-10-CM Diagnosis Code I27.21

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Secondary pulmonary arterial hypertension

  • I27.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM I27.21 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of I27.21 – other international versions of ICD-10 I27.21 may differ.

Applicable To

  • (Associated) (drug-induced) (toxin-induced) pulmonary arterial hypertension NOS
  • (Associated) (drug-induced) (toxin-induced) (secondary) group 1 pulmonary hypertension

Code Also

  • associated conditions if applicable, or adverse effects of drugs or toxins, such as:
  • adverse effect of appetite depressants (T50.5X5)
  • congenital heart disease (Q20-Q28 )
  • human immunodeficiency virus [HIV] disease (B20)
  • polymyositis (M33.2-)
  • portal hypertension (K76.6)
  • rheumatoid arthritis (M05.-)
  • schistosomiasis (B65.-)
  • Sjögren syndrome (M35.0-)
  • systemic sclerosis (M34.-)

The following code(s) above I27.21 contain annotation back-references

 that may be applicable to I27.21:

  • I00-I99  Diseases of the circulatory system
  • I27.2  Other secondary pulmonary hypertension

ICD-10-CM I27.21 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 314 Other circulatory system diagnoses with mcc
  • 315 Other circulatory system diagnoses with cc
  • 316 Other circulatory system diagnoses without cc/mcc

Convert I27.21 to ICD-9-CMCode History

  • 2018 (effective 10/1/2017): New code
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to I27.21:

  • Code Also: M34.81
  • Type 1 Excludes: I27.0

Diagnosis Index entries containing back-references to I27.21:

  • Hypertension, hypertensive (accelerated) (benign) (essential) (idiopathic) (malignant) (systemic) I10
    • pulmonaryI27.20
      • secondary
        • arterial I27.21
      • arterial I27.21 (associated) (drug-induced) (toxin-induced)
      • group 1 I27.21 (associated) (drug-induced) (toxin-induced)
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