2025 ICD-10-CM Diagnosis Code I51.81

by

Takotsubo syndrome

  • I51.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM I51.81 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of I51.81 – other international versions of ICD-10 I51.81 may differ.

Applicable To

  • Reversible left ventricular dysfunction following sudden emotional stress
  • Stress induced cardiomyopathy
  • Takotsubo cardiomyopathy
  • Transient left ventricular apical ballooning syndrome

The following code(s) above I51.81 contain annotation back-references

 that may be applicable to I51.81:

  • I00-I99  Diseases of the circulatory system
  • I51  Complications and ill-defined descriptions of heart disease

Approximate Synonyms

  • Takotsubo cardiomyopathy

Clinical Information

  • A rare disorder characterized by transient left ventricular wall systolic dysfunction, resulting in apical ballooning appearance, chest pain, and st segment elevation.
  • A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ecg) t wave inversions. This abnormality is associated with high levels of catecholamines, either administered or endogenously secreted from a tumor or during extreme stress.

ICD-10-CM I51.81 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 314 Other circulatory system diagnoses with mcc
  • 315 Other circulatory system diagnoses with cc
  • 316 Other circulatory system diagnoses without cc/mcc

Convert I51.81 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to I51.81:

  • Code First: I5A

Diagnosis Index entries containing back-references to I51.81:

  • Cardiomyopathy (familial) (idiopathic) I42.9
    • stress induced I51.81
    • takotsubo I51.81
  • Dysfunction
    • ventricularI51.9
      • left, reversible, following sudden emotional stress I51.81
    • left ventricular, following sudden emotional stress I51.81
  • Syndrome – see also Disease
    • apical ballooning I51.81 (transient left ventricular)
    • takotsubo I51.81
    • transient left ventricular apical ballooning I51.81
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