2025 ICD-10-CM Diagnosis Code Z17.420

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Hormone receptor negative with human epidermal growth factor receptor 2 positive status

  • Z17.420 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Hormone recept neg w hmn epdrml grth fctr recept 2 pos stat
  • ICD-10-CM Z17.420 is a new 2025 ICD-10-CM code that became effective on October 1, 2024.
  • This is the American ICD-10-CM version of Z17.420 – other international versions of ICD-10 Z17.420 may differ.

Applicable To

  • HR- with HER2+

The following code(s) above Z17.420 contain annotation back-references

 that may be applicable to Z17.420:

  • Z00-Z99  Factors influencing health status and contact with health services
  • Z17  Estrogen, and other hormones and factors receptor status
  • Z17.4  Combined receptor status
  • Z17.42  Hormone receptor negative

Present On Admission

  • Z17.420 is considered exempt from POA reporting.

ICD-10-CM Z17.420 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 951 Other factors influencing health status

Code History

  • 2025 (effective 10/1/2024): New code

Diagnosis Index entries containing back-references to Z17.420:

  • Status (post) – see also Presence (of)
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