2024 ICD-10-CM Diagnosis Code B00.4

Herpesviral encephalitis

  • B00.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM B00.4 became effective on October 1, 2023.
  • This is the American ICD-10-CM version of B00.4 – other international versions of ICD-10 B00.4 may differ.

Applicable To

  • Herpesviral meningoencephalitis
  • Simian B disease

Type 1 Excludes

  • herpesviral encephalitis due to herpesvirus 6 and 7 (B10.01B10.09)
  • non-simplex herpesviral encephalitis (B10.0-)

The following code(s) above B00.4 contain annotation back-references

 that may be applicable to B00.4:

  • A00-B99  Certain infectious and parasitic diseases
  • B00  Herpesviral [herpes simplex] infections

Approximate Synonyms

  • Encephalitis due to human herpes simplex virus
  • Herpes simplex encephalitis
  • Herpes simplex meningoencephalitis
  • Herpetic meningoencephalitis

Clinical Information

  • A serious viral disorder characterized by infection of the brain by herpes simplex virus type 1 or 2. Herpes simplex virus type 1 affects adults, whereas herpes simplex virus type 2 affects newborns. Signs and symptoms include fever, headaches, vomiting, seizures and psychiatric manifestations.
  • An acute (or rarely chronic) inflammatory process of the brain caused by simplexvirus infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (herpesvirus 1, human) and less often by human herpesvirus 2 (herpesvirus 2, human). Clinical manifestations include fever; headache; seizures; hallucinations; behavioral alterations; aphasia; hemiparesis; and coma. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior temporal lobe and orbital regions of the frontal lobe. (from Adams et al., Principles of Neurology, 6th ed, pp751-4)

ICD-10-CM B00.4 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):

  • 023 Craniotomy with major device implant or acute complex cns principal diagnosis with mcc or chemotherapy implant or epilepsy with neurostimulator
  • 024 Craniotomy with major device implant or acute complex cns principal diagnosis without mcc
  • 097 Non-bacterial infection of nervous system except viral meningitis with mcc
  • 098 Non-bacterial infection of nervous system except viral meningitis with cc
  • 099 Non-bacterial infection of nervous system except viral meningitis without cc/mcc
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 974 Hiv with major related condition with mcc
  • 975 Hiv with major related condition with cc
  • 976 Hiv with major related condition without cc/mcc

Convert B00.4 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change

Code annotations containing back-references to B00.4:

Diagnosis Index entries containing back-references to B00.4: