2025 ICD-10-CM Diagnosis Code E22.0

Acromegaly and pituitary gigantism

  • E22.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM E22.0 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E22.0 – other international versions of ICD-10 E22.0 may differ.

Applicable To

  • Overproduction of growth hormone

Type 1 Excludes

  • constitutional gigantism (E34.4)
  • constitutional tall stature (E34.4)
  • increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)

The following code(s) above E22.0 contain annotation back-references

 that may be applicable to E22.0:

  • E00-E89  Endocrine, nutritional and metabolic diseases
  • E20-E35  Disorders of other endocrine glands
  • E22  Hyperfunction of pituitary gland

Approximate Synonyms

  • Acromegaly
  • Growth hormone overproduction
  • Hypersomatotropic gigantism
  • Overproduction of growth hormone
  • Pituitary gigantism
  • Sotos syndrome
  • Sotos’ syndrome

ICD-10-CM E22.0 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E22.0 to ICD-9-CMCode History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Code annotations containing back-references to E22.0:

  • Type 1 Excludes: M26.0

Diagnosis Index entries containing back-references to E22.0:

  • Acromegaly, acromegalia E22.0
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
    • due to or associated with
      • acromegaly E22.0
    • in (due to)
      • acromegaly E22.0 – see also subcategory M14.8-
  • ArthropathyM12.9 – see also Arthritis
    • in (due to)
      • acromegaly E22.0
  • Erdheim’s syndrome E22.0 (acromegalic macrospondylitis)
  • Gigantism (cerebral) (hypophyseal) (pituitary) E22.0
  • Hypersecretion
    • hormone(s)
      • growth E22.0
  • Hypophyseal, hypophysis – see also condition
    • gigantism E22.0
  • Launois’ syndrome E22.0 (pituitary gigantism)
  • Macrospondylitis , acromegalic E22.0
  • Marie’s
    • disease or syndrome E22.0 (acromegaly)
  • Overproduction – see also Hypersecretion
    • growth hormone E22.0
  • Scaglietti-Dagnini syndrome E22.0
  • Syndrome – see also Disease
    • cerebral
      • gigantism E22.0
    • costovertebral E22.0
    • Erdheim’s E22.0
    • Launois’ E22.0
    • Marie’s E22.0 (acromegaly)
    • pituitary E22.0
    • Scaglietti-Dagnini E22.0
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